Effect of dichloromethylene diphosphonate (Cl2MDP) on immune function in breast cancer patients with bone metastases |
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| Authors: | Ritva Markkula Heikki Repo Marjatta Leirisalo Carl Blomqvist Inkeri Elomaa |
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| Institution: | 1. Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki 29, Finland
2. Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Helsinki, Finland
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| Abstract: | Immune function was studied in normocalcemic breast cancer patients with bone metastases treated with either dichloromethylene diphosphonate (Cl2MDP) or placebo. The results showed no significant difference between the two patient groups. This suggests that Cl2MDP does not markedly impair the host's defense mechanisms, and in this respect can be safely used in the treatment of patients with resorptive bone disease. |
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