The effect of selenium on cell proliferation in liver and colon |
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Authors: | Margaret A Tempero Eleanor E Deschner Morris S Zedeck |
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Institution: | (1) Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Dewey Avenue, 68105 Omaha, Nebraska;(2) the Veterans Administration Medical Center, Omaha, Nebraska;(3) the Memorial Sloan Kettering Cancer Center, New York, New York |
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Abstract: | Epidemiologic and experimental evidence support a chemoprotective role for selenium (Se) in malignancy. Many mechanisms have
been proposed to explain this phenomenon. In this study, the effect of Se intake on proliferation of hepatocytes and normal
colonic epithelial cells in rats was determined using autoradiographic analysis of thymidine incorporation into DNA. Hepatocyte
proliferation was measured 24 h after partial hepatectomy. Selenium-dosed animals demonstrated a significant reduction in
hepatocyte labeling compared to the control group (6.1±2.6 vs 29.2±15.6,p=0.003). However, Se dosing did not affect the thymidine-labeling indices or distribution of labeling in colonic epithelium.
Selenium may inhibit cell proliferation when it is the result of an unusually intense stimulus. This finding could explain
in part the inhibitory effect of Se in some experimental cancer models.
Dr. Tempero is a recipient of a Junior Clinical Faculty Fellowship from the American Cancer Society. |
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Keywords: | Selenium chemoprotective role of in malignancy selenium intake effect of on cell proliferation liver colon carcino-genesis |
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