Reduction of physical assignments to a standard lod table: Chromosome 1 |
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Authors: | B J B Keats N E Morton D C Rao |
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Institution: | (1) Population Genetics Laboratory, University of Hawaii, 1980 East West Road, 96822 Honolulu, HI, USA;(2) Present address: Division of Biostatistics, Dept. of Preventive Medicine, Washington University, 4566 Scott Avenue, Box 8067, 63110 St. Louis, MO, USA;(3) Dept. of Psychiatry, Washington University, 4566 Scott Avenue, Box 8067, 63110 St. Louis, MO, USA;(4) Dept. of Genetics, Washington University, 4566 Scott Avenue, Box 8067, 63110 St. Louis, MO, USA |
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Abstract: | Summary A method for reducing physical assignments of markers to a lod score table is described, and these tables are added to those from family data to provide a consistent genetic map of chromosome 1. Various chiasma maps are considered, and the results suggest that terminalization of chiasmata does occur. Chiasmata appear to be significantly less localized in oocytes than spermatocytes, and crossing-over in the vicinity of the centromere is more common in females than in males.This work was supported by Grants GM 23021, GM 24941, and NF 1-475 from the U.S. National Institutes of Health and National Foundation, PGL Paper No. 228 |
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