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Evasion and exploitation of chemokines by viruses |
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| Authors: | Lalani A S McFadden G |
| Affiliation: | a Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, HSE 401, 513 Parnassus Avenue, San Francisco, CA 94143-0414, USA b J.P. Robarts Research Institute and the Department of Microbiology and Immunology, University of Western Ontario, Rm. 133 SDRI, 1400 Western Road, London, Ontario, Canada, N6G 2V4 |
| Abstract: | Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders. |
| Keywords: | Herpesvirus Kaposi’s sarcoma Poxvirus Chemokine Virokine Viroceptor |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |