Frequency dependence of water proton longitudinal nuclear magnetic relaxation times in mouse tissues at 20°C |
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Authors: | J.M. Escanye D. Canet J. Robert |
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Affiliation: | 1. Laboratoire de Biophysique, Faculté B de Médecine, Université de Nancy-1, 18 rue Lionnois, F-54000 Nancy France;2. Laboratoire de Chimie Théorique, Equipe de Recherche associée au C.N.R.S. N°22, Université de Nancy-1, B.P. 239, F-54506 Vandoeuvre-Nancy Cédex France |
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Abstract: | We have measured the proton longitudinal relaxation times of tissue water of healthy and tumor-bearing mice as a function of the Larmor frequency in the range 6.7 to 90 MHz. These data can be rationalized according to , where A and B are constants specific to the tissue species. We present an interpretation of this frequency dependence within the Fast Exchange Two States model. It is shown that involving a distribution of correlation times for water proton-proton interaction does not yield consistent results, whereas a physically meaningful translational diffusion model pertinent to the dipolar interaction between water protons and macromolecules protons leads to the required frequency dependence. Essentially tissues would differ by the ‘bound’ versus ‘free’ proportion, or by structural properties of cells, rather than by the time-scales governing water motion. |
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Keywords: | NMR, Relaxation time Tissue water Frequency dependence (Mouse) |
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