THE 4-O-METHYL METABOLITES OF CATECHOLAMINES IN MAN: CHROMATOGRAPHIC IDENTIFICATION OF 3-HYDROXY,4-METHOXYPHENYLACETIC ACID (HOMO-ISO-VANILLIC ACID) IN CEREBROSPINAL FLUID |
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| Authors: | P Mathieu L Revol P Trouillas |
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| Institution: | Laboratoire de biologie de I'hôpital psychiatrique de Vinatier, and Clinique neuro-pyschiatrique de la Faculté, 95, boulevard Pinel, 69-Lyon-Bron, France |
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| Abstract: | Abstract— The isomeric phenolic acids, homovanillic acid (4-hydroxy,3-methoxyphenylacetic acid) and homo-iso-vanillic acid (3-hydroxy,4-methoxyphenylacetic acid), were separated and identified by means of paper chromatography of their azo-derivatives with diazotized para-nitroaniline. Using this chromatographic procedure, homo-iso-vaniliic acid was identified in several samples of human cerebrospinal fluid, an observation which suggests that dopamine may be partly metabolized in brain, with the production of 4-methoxy derivatives. |
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