An empirically derived approach to the classification and
diagnosis of mood disorders |
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Authors: | DREW WESTEN JOHANNA C MALONE JARED A DEFIRE |
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Institution: | 1Department of Psychology and Psychiatry, Emory University, 36 Eagle Row, Atlanta, GA 30322;2Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA |
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Abstract: | This article describes a system for diagnosing mood disorders that is empirically
derived and designed for its clinical utility in everyday practice. A ran-dom
national sample of psychiatrists and clinical psychologists described a randomly
selected current patient with a measure designed for clinically ex-perienced
informants, the Mood Disorder Diagnostic Questionnaire (MDDQ), and completed
additional research forms. We applied factor analysis to the MDDQ to identify
naturally occurring diagnostic groupings within the patient sample. The analysis
yielded three clinically distinct mood disorder dimen-sions or spectra, consistent
with the major mood disturbances included in the DSM and ICD over successive
editions (major depression, dysthymia, and mania), along with a suicide risk
index. Diagnostic criteria were determined strictly empirically. Initial data
using diagnostic efficiency statistics sup-ported the accuracy of the dimensions
in discriminating DSM-IV diagnoses; regression analyses supported the discriminant
validity of the MDDQ scales; and correlational analysis demonstrated coherent
patterns of association with family history of mood disorders and functional
outcomes, supporting va-lidity. Perhaps most importantly, the MDDQ diagnostic
scales demonstrated incremental validity in predicting adaptive functioning
and psychiatric his-tory over and above DSM-IV diagnosis. The empirically
derived syndromes can be used to diagnose mood syndromes dimensionally without
complex di-agnostic algorithms or can be combined into diagnostic prototypes
that eliminate the need for ever-expanding categories of mood disorders that
are clini-cally unwieldy. |
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Keywords: | Mood disorders suicidality depression dimensional diagnosis prototype matching |
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