|
|||||
|
|
Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis |
|
| Authors: | María Teruel Carmen P Simeon Jasper Broen Madelon C Vonk Patricia Carreira Maria Teresa Camps Rosa García-Portales Esmeralda Delgado-Frías Maria Gallego Gerard Espinosa the Spanish Scleroderma Group Lorenzo Beretta Paolo Airó Claudio Lunardi Gabriela Riemekasten Torsten Witte Thomas Krieg Alexander Kreuter J?rg HW Distler Nicolas Hunzelmann Bobby P Koeleman Alexandre E Voskuyl Annemie J Schuerwegh Miguel ángel González-Gay Timothy RDJ Radstake Javier Martin |
| Institution: | 1. Instituto de Parasitolog??a y Biomedicina L??pez-Neyra, IPBLN-CSIC, Avda. del Conocimiento s/n. 18010, Granada, SpainArmilla (Granada), Spain 2. Department of Internal Medicine, Hospital Valle de Hebron, Passeig de la Vall d??Hebron 119, 08035, Barcelona, Spain 3. Department of Rheumatology, Radboud University Nijmegen Medical Centre, Comeniuslaan 4, 6525 HP, Nijmegen, The Netherlands 4. Department of Rheumatology, Hospital 12 de Octubre, Avda. de C??rdoba s/n 28041, Madrid, Spain 5. Department of Internal Medicine, Hospital Carlos Haya, Avda Carlos Haya s/n 29010, M??laga, Spain 6. Department of Rheumatology, Hospital Virgen de la Victoria, Campus de Teatinos s/n 29010, M??laga, Spain 7. Department of Rheumatology, Hospital Universitario de Canarias, Ctra. Cuesta-Taco, s/n 38320, La Cuesta, San Crist??bal de La Laguna, Tenerife, Canarias, Spain 8. Department of Internal Medicine, Hospital Central de Asturias, Celestino Villamil, s/n 33006, Oviedo, Spain 9. Department of Autoimmune Diseases, Hospital Clinic, Carrer de Villarroel, 170 08036, Barcelona, Spain 11. Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca?? Granda Ospedale Maggiore Policlinico Via Francesco Sforza, 35 20122 and University of Milan, Via Festa del Perdono, 7, 20122, Milan, Italy 12. Rheumatology Unit and Chair, Spedali Civili, Universit?? degli Studi, Piazzale Spedali Civili, 1, 25123, Brescia, Italy 13. Department of Medicine, Policlinico GB Rossi, Universit?? degli studi di Verona, Via dell??Artigliere, 8, 37129, Verona, Italy 14. Department of Rheumatology and Clinical Immunology, Charit?? University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Charit??platz 1, 10117, Berlin, Germany 15. Clinic for Immunology and Rheumatology Medical School, Carl-Neuberg-Str, 1, 30625, Hannover, Germany 16. Department of Dermatology, University of Cologne, Kerpener Str 62, 50924, K?ln, Germany 17. Department of Dermatology, Allergology, and Venereology, Ruhr University of Bochum, Stiepeler Stra?e 129, 44801, Bochum, Germany 18. Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Schillerstra?e 1, 91054, Erlangen, Germany 19. Section Complex Genetics, Department of Medical Genetics, University Medical Center Utrecht, Universiteitsweg Stratenum, 3508 AB, Utrecht, The Netherlands 20. Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, 1081 HZ, Amsterdam, The Netherlands 21. Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands 22. Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Avda. Valdecilla, 25, 39008, Santander, Spain 23. Department of Rheumatology and Clinical Immunology, University Utrecht Medical Center, Universiteitsweg 100 Stratenum, 3508 AB, Utrecht, The Netherlands |
| Abstract: | IntroductionThe aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).MethodsIn total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.ResultsNo evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.ConclusionsOur results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |