Competing endogenous RNA database |
| |
Authors: | Aaron L Sarver Subbaya Subramanian |
| |
Institution: | 1Masonic Cancer Center;2Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MN 55455 |
| |
Abstract: | A given mRNA can be regulated by interactions with miRNAs and in turn the availability of these miRNAs can be regulated by
their interactions with alternate mRNAs. The concept of regulation of a given mRNA by alternate mRNA (competing endogenous
mRNA) by virtue of interactions with miRNAs through shared miRNA response elements is poised to become a fundamental
genetic regulatory mechanism. The molecular basis of the mRNA-mRNA cross talks is via miRNA response elements, which can
be predicted based on both molecular interaction and evolutionary conservation. By examining the co-occurrence of miRNA
response elements in the mRNAs on a genome-wide basis we predict competing endogenous RNA for specific mRNAs targeted by
miRNAs. Comparison of the mRNAs predicted to regulate PTEN with recently published work, indicate that the results presented
within the competing endogenous RNA database (ceRDB) have biological relevance.Availabilityhttp://www.oncomir.umn.edu/cefinder/ |
| |
Keywords: | ceRNAs MRE microRNA response elements database competing endogenous RNAs database ceRDB |
|