Comparison of two marine sponge-associated<Emphasis Type="Italic">Penicillium</Emphasis> strains DQ25 and SC10: differences in secondary metabolites and their bioactivities |
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| Authors: | Email author" target="_blank">Rongbian?WeiEmail author Fuchao?Li Ru?Song Email author" target="_blank">Song?QinEmail author |
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| Institution: | 1.School of Life Sciences and Technology,China Pharmaceutical University,Nanjing;2.College of Marine Science,Zhejiang Ocean University,Zhoushan;3.Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology,Chinese Academy of Sciences,Qingdao;4.College of Food Science,Ocean University of China,Qingdao,P. R. China |
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| Abstract: | Two strains ofPenicillium, DQ25 and SC10, isolated from marine spongeHaliclona angulata (Bowerbank) andHymeniacidon sp. respectively, were subjected to stationary cultivation under GYP medium for 30 days. The fermentation extracts were undergone bioactivities assays against human pathogens, phytopathogenic fungi and brine shrimp (Artemia salina). Bioassays-guided compounds isolation was performed by Silica gel columns and Sephadex LH-20 chromatography. Spectroscopic methods were used to structures elucidation of the compounds. Results showed the activities of secondary metabolites of strain DQ25 were generally stronger than that of strain SC10. Major bioactive molecules isolated from strain DQ25 were a 1,4-naphthoquinone derivative and an unidentified alkaloid. The two components were not isolated from the extract of strain SC10. ITS sequences revealed that these two species have the greatest similarity withPenicillium vinaceum andPenicillium granulatum respectively. |
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