Developmental expression of transforming growth factors alpha and beta in mouse fetus. |
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| Authors: | J N Wilcox and R Derynck |
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| Affiliation: | Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080. |
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| Abstract: | Expression of mRNA for transforming growth factor alpha (TGF-alpha) and TGF-beta 1 during the fetal development of mice was evaluated by in situ hybridization. TGF-alpha mRNA was detected in 9- and 10-day fetuses but was absent in older fetuses. TGF-alpha mRNA-containing cells were found in the placenta, otic vesicle, oral cavity, pharyngeal pouch, first and second branchial arches, and developing kidneys. mRNA for TGF-beta 1 was present in hematopoietic cells of blood islands and capillaries and in the liver as it began to bud off on day 10 and function as a hematopoietic organ. |
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