树鼩血压和心率的无创测定

目的建立健康树鼩的心率、血压正常值参考范围,并探讨不同来源、不同性别、不同年龄树鼩心率、血压的差异。方法随机挑选实验树鼩180只,按来源分为野生成年组、F1代自繁成年组和青幼年组三个组,每组雌雄各半,共60只。采用智能无创血压计（鼠仪）逐只测定HR（心率）、SBP（收缩压）、DBP（舒张压）和MBP（平均动脉压）。结果野生成年树鼩、自繁成年树鼩和青幼年树鼩心率分别为394.33±37.74 BPM、351.61±72.76 BPM和378.19±69.04 BPM,野生和自繁成年树鼩组差异有显著性（P〈0.05）。自繁成年树鼩收缩压、舒张压和平均动脉压均明显低于青幼年树鼩,差异有极显著性（P〈0.01）。野生成年树鼩和自繁成年树鼩相比,收缩压、舒张压和平均动脉压差异均无显著性（P〉0.05）。结论大鼠无创血压计适合于树鼩的血压、心率的测量。通过测定,获得了野生成年树鼩、F1代自繁成年树鼩和青幼年树鼩的心率和血压参考值范围,丰富了树鼩基础生理数据,可为相关研究提供科学参考。

Noninvasive measurement of blood pressure and heart rate in tree shrews

Objective To establish the normal reference values of heart rate （HR） and hlood pressure （BP） of healthy tree shrews, and discuss the differences of HR and BP in tree shrews of different sources, sex and age. Methods One hundred eighty tree shrews were randomly divided in three groups： wild adult group, F1 generation artificial breeding adult group and juvenile group. Each group included 60 animals （ half female and half male）. An indirect blood pressure meter（BP-98A, Softron）was used to measure the heart rate （HR）, systolic blood pressure （SBP）, diastolic blood pressure （DBP） and mean arterial pressure （MBP）. Results The HR of wild adult, artificial breeding adult and juvenile tree shrews were 394. 33 ~ 37.74 BPM, 351.61 ~ 72.76 BPM, and 378.19 ~ 69. 04 BPM, respectively. There was a significant difference between the wild adult and artificial breeding adult tree shrew groups （ P 〈 0. 05 ）. The SBP, DBP and MBP of artificial breeding adult group were very significantly lower than those of juvenile group （ P 〈 0. 01 ）. There were no significant differences between the SLIP, DBP and MBP of wild adult and artificial breeding adult groups （P 〉 0.05 ）. Conclusions The rat indirect blood pressure meter （ Softron, BP-98A ） is suitable for measurement of blood pressure and heart rate of tree shrews. The HR and BP of wild adult, F1 generation of artificial breeding adult and juvenile tree shrews obtained in this study enriched the basic physiological data o tree shrews and provide scientific reference for relevant researches.