| Fibulin-5在三阴型乳腺癌细胞侵袭中的功能研究 |
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| 引用本文： | 周树敏,胡斌,牛鑫,郭尚春,刘鹃,汪泱. Fibulin-5在三阴型乳腺癌细胞侵袭中的功能研究[J]. 现代生物医学进展, 2013, 0(23): 4406-4409 |
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| 作者姓名： | 周树敏 胡斌 牛鑫 郭尚春 刘鹃 汪泱 |
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| 作者单位： | 上海交通大学附属第六人民医院四肢显微外科研究所,上海200233 |
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| 基金项目： | 国家自然科学基金项目（81272170） |
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| 摘 要： | 的：研究Fibulin-5蛋白在三阴性乳腺癌（TNBC）m胞转移中的作用。方法：以三阴性乳腺癌细胞系（MDA-MB-231）分化而来的三株高中低不同转移能力的子细胞系为模型，高表达和抑制Fibulin．5在其中的表达，研究其对细胞侵袭能力的影响。结果：三阴性乳腺癌细胞内本底的Fibulin．5与其转移能力正相关，另外上调和抑制Fibulin-5可以改变其原有的侵袭能力。结论：Fibulin-5在三阴性乳腺癌细胞转移中发挥重要作用，抑制Fibulin-5可以降低三阴性乳腺癌细胞的侵袭能力。
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| 关 键 词： | Fibulin-5 细胞外基质 三阴性乳腺癌 肿瘤转移 |
Study of Fibulin-5 Role in the Invasive Ability of Triple Negative Breast Cancer Cells |
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| ZHOU Shu-min,HU Bin,N,U Xin,GUO Shang-chun,LIU Juan,WANG Yang. Study of Fibulin-5 Role in the Invasive Ability of Triple Negative Breast Cancer Cells[J]. Progress in Modern Biomedicine, 2013, 0(23): 4406-4409 |
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| Authors: | ZHOU Shu-min HU Bin N U Xin GUO Shang-chun LIU Juan WANG Yang |
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| Affiliation: | (The Institute of Limbs Microsurgety, the Sixth People＇s Hospital Aflliated to Shanghai Jiao Tong University, Shanghai, 200233, China) |
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| Abstract: | Objective： To study the biological function of Fibulin-5 in triple negative breast cancer （TNBC）. Methods： Three single cell progenies of high, middle and low metastatic abilities derived from TNBC cell line （MDA-MB-231） were employed as a model in this study. The biological functions on cell invasions of overexpressing and silence of Fibulin-5 in these cell lines were analyzed by transwell assays. Result： The native expression level of fibulin-5 is highly related to the metastatic abilities of TNBC cells. Moreover, overexpressing and silence of Fibulin-5 will up-regulate and inhibiter the invasions of TNBC cells, respectively. Conclusion： Fibulin-5 plays a great role in TNBC metastasis and the silence of Fibulin-5 in TNBC cell will inhibit the metastasis of TNBC. |
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| Keywords: | Fibulin-5 ECM TNBC Metastasis |
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