BCTC和辣椒辣素对卵清蛋白致敏大鼠气管平滑肌张力的影响

目的：评价BCTC和辣椒辣素对气道高反应性大鼠气管平滑肌张力的影响。方法：健康成年SD大鼠32只，每只大鼠第1天和第8天腹腔加皮下注射卵清蛋白致敏，第15天连续雾化吸入卵清蛋白（OVA）三天，激发建立哮喘模型。分离气管平滑肌，随机分为四组，0组（Ovalbumin）卵清蛋白组，OC组（Ovalbumin＋capsaicin）卵清蛋白＋辣椒辣素组，0B组（Ovalbumin＋BCTC），DSMO组（DSMO＋Ovalbumin）溶剂组。分别在4组溶液的刺激下测定离体气管平滑肌张力的变化。结果：离体气管平滑肌的张力OC组较0组为高；O组气管平滑肌张力比0B组高。结论：辣椒辣素增加致敏离体气管平滑肌张力，BCTC能够降低致敏大鼠气管平滑肌张力，对致敏离体平滑肌有松弛作用。

Effect of BCTC and Capsaicin on Ovalbumin-induced Smooth Muscle Contraction of the Sensitized Rat Trachea

Objective： To examine the effects of BCTC and capsaicin on ovalbumin （OVA）-induced contraction of OVA sensi- tized rats trachea with hyper responsiveness. Methods： 32 Male, adult, SD rats were sensitized with OVA mixed with aluminum hydrox- ide by injection in intraperitoneal and subcutaneous in first day and eighth day,then we performed OVA aerosol inhalation to the rats for 3 consecutive days, to stimulate and establish asthma model.Isolated trachea smooth muscles were randomly divided into four groups, O group （Ovalbumin）, OC group （Ovalbtmain＋capsaicin）, OB group （Ovalbumin＋BCTC）, DSMO group （DSMO＋Ovalbumin） solvent group, and we observed effects of BCTC and capsaicin on OVA-induced trachea smooth muscle contraction. Results： OC group has a higher trachea smooth muscle than O group. OB group has a lower contraction than O group. Conclusion： Capsaicin can increase con- traction of the OVA-sensitized, isolated trachea smooth muscle; BCTC can attenuate contraction of OVA-induced ,isolated trachea smooth muscle of sensitized rats, and can relax OVA-sensitized,isolated trachea smooth muscle.