Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7 |
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| Authors: | Fretland Adrian J Safe Stephen Hankinson Oliver |
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| Affiliation: | Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, Center for Health Sciences, University of California, Los Angeles, CA 90095-1732, USA. |
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| Abstract: | |
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| Keywords: | AHR, aryl hydrocarbon receptor ARNT, aryl hydrocarbon receptor nuclear translocator AHRC, AHR-ARNT complex ChIP, chromatin immunoprecipitation CYP1A1, cytochrome P4501A1 DIM, diindolylmethane ER, estrogen receptor Hepa-1, Hepa-1c1c7 IP, immunoprecipitation 6-MCDF, 6-alkyl-1,3,8-trichlorodibenzofuran SAhRM, selective aryl hydrocarbon receptor modulator SERM, selective estrogen receptor modulator TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin XRE, xenobiotic responsive element |
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