Structural basis of mRNA cap recognition by proteins |
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| Authors: | Quiocho F A Hu G Gershon P D |
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| Institution: | Department of Biochemistry and the Structural and Computational Biology, Howard Hughes Medical Institute, Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA. faq@bcm.tmc.edu |
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| Abstract: | Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains. The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase. |
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