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Evidence that the Echinococcus granulosus G6 genotype has an affinity for the brain in humans |
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| Authors: | SM Sadjjadi F Mikaeili M Karamian S Maraghi FS Sadjjadi S Shariat-Torbaghan EB Kia |
| Institution: | 1. Dept. of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;3. Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;4. Dept. of Parasitology and Mycology, Abadan Arvand International University of Medical Sciences, Infectious and Tropical Diseases Research Center, Thalassemia and Haemoglobinopathy Research Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran;5. Dept. of Biology, Shiraz University, Shiraz, Iran;6. Dept. of Pathology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran |
| Abstract: | The present study investigates the molecular characteristics of cerebral Echinococcus cysts. A total of 10 specimens of cerebral Echinococcus cysts, including six formalin-fixed paraffin blocks and four intact cerebral cysts, were used for this study. The target DNA was successfully amplified from eight samples and sequenced. BLAST analysis indicated that sequenced isolates belong to the Echinococcus granulosus (G6) genotype. All of the eight sampled brain cysts belonged to the G6 genotype, while all of the eight liver cysts belonged to G1. This is a strong indication that G6 has a higher affinity for the human brain than G1. |
| Keywords: | Echinococcus granulosus G6 genotype Brain Human Echinococcus cyst Echinococcosis |
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