A circulating thyroid peroxidase-like substance in healthy human peripheral blood |
| |
| Authors: | T Kotani S Ohtaki |
| |
| Institution: | Central Laboratory of Clinical Investigation, Miyazaki Medical College Hospital, Japan. |
| |
| Abstract: | Circulating thyroid peroxidase (TPO)-like substance in healthy human peripheral blood was studied to clarify the immunological role of TPO. By using a highly sensitive radioimmunoassay system combined with murine monoclonal antibodies, TPO-like substance was measurable in 6 out of 84 sera. Characterization of this circulating substance by gel filtration revealed that the molecular weight of a major peak corresponded to that of trypsinized TPO. From these findings it is possible that peripheral blood lymphocytes are exposed to a low level of TPO as well as to thyroglobulin. |
| |
| Keywords: | |
|
|
