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Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2 |
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| Authors: | Zhang Xiaoyan Urbanski Maud Patel Mona Cox Geoffrey G Zeck Roxanne E Bian Haiyan Conway Bruce R Beavers Mary Pat Rybczynski Philip J Demarest Keith T |
| Institution: | Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. xzhang11@prdus.jnj.com |
| Abstract: | A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats. |
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