APC: the plot thickens. |
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| Authors: | M Bienz |
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| Institution: | Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. mb2@mrc-lmb.cam.ac.uk. |
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| Abstract: | Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive. |
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