The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population |
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Authors: | Peng Huang Haozhi Fan Ting Tian Peiwen Liao Jun Li Rongbin Yu Xueshan Xia Yue Feng Jie Wang Yuan Liu Yun Zhang Ming Yue |
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Institution: | 1.Department of Epidemiology and Biostatistics, School of Public Health,Nanjing Medical University,Nanjing,China;2.Institute of Epidemiology and Microbiology,Huadong Research Institute for Medicine and Biotechnics,Nanjing,China;3.Pubilc Health Sciences Department,Karolinska Institute,Solna,Sweden;4.Department of Infectious Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,China;5.Faculty of Life Science and Technology,Kunming University of Science and Technology,Yunnan,China;6.Department of Basic and Community Nursing, School of Nursing,Nanjing Medical University,Nanjing,China |
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Abstract: | BackgroundRecently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection.MethodsThe rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay.ResultsLogistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR?=?1.33, 95% CI: 1.04–1.71, P?=?0.026) and additive models (adjusted OR?=?1.30, 95% CI: 1.06–1.60, P?=?0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR?=?1.52, 95% CI: 1.01–2.28, P?=?0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR?=?1.37, 95% CI: 1.05–1.78, P?=?0.018).ConclusionThe HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively. |
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