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Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
Authors:Jing Xiong  Tiefen Su  Pengcheng Zhu  Qilin Ao  Qiurong Ruan  Guoping Wang
Institution:1.Institute of Pathology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,People’s Republic of China;2.Department of Pathology, School of Basic Medical Science, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,People’s Republic of China
Abstract:

Background

Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation.

Case presentation

In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis.

Conclusion

To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission.
Keywords:
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