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Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome |
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| Authors: | Michael Sand Samuel Uecker Falk G Bechara Marcos Gelos Daniel Sand Till H Wiese Benno Mann |
| Affiliation: | 1.Department of General and Visceral Surgery,Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum,Germany;2.Department of Dermatology and Allergology,Ruhr-University Bochum,Germany;3.Department of Physiological Science,University of California Los Angeles (UCLA),USA;4.Department of Radiology, Augusta Krankenanstalt,Academic Teaching Hospital of the Ruhr-University Bochum,Germany |
| Abstract: | Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS).We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis. |
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