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Heterogeneous turnover of terminal and core sugars within the carbohydrate chain of dipeptidylaminopeptidase IV isolated from rat liver plasma membrane |
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| Authors: | Brigitte A Volk Wolfgang Kreisel Eckart Köttgen Wolfgang Gerok Werner Reutter |
| Institution: | 1. Medizinische Klinik der Albert-Ludwigs-Universität, D-7800 Freiburg, FRG;2. Institut für Molekularbiologie und Biochemie der Freien Universität, Dahlem, D-1000 Berlin 33, Germany |
| Abstract: | Dipeptidylaminopeptidase IV, a plasma membrane-bound glycoprotein, is characterized by an intramolecular heterogeneous turnover of the protein backbone and carbohydrate chain. The faster turnover of the latter is restricted only to the outer sugars. The inner core sugars D-mannose and N-acetyl-D-glucosamine turn over at the same rate as the protein backbone. |
| Keywords: | Plasma membrane Glycoprotein Dipeptidylaminopeptidase IV Intramolecular heterogeneous turnover D-Mannose D-Glucosamine |
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