Inability of [125I]Sar1, Ile8-Angiotensin II to Move Between the Blood and Cerebrospinal Fluid Compartments |
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| Authors: | J W Harding M J Sullivan J M Hanesworth L L Cushing J W Wright |
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| Institution: | Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman 99164-6520. |
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| Abstract: | The angiotensin II competitive antagonist 125I]-Sar1, Ile8-angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition 125I]Sar1, Ile8-angiotensin II lacked the capacity to move in the opposite direction over a 20-min collection period following cerebroventricular infusion. These data suggest that angiotensins lack the capacity to move freely between the blood and cerebrospinal fluid compartments and are consistent with the notion that blood-borne and cerebroventricular angiotensins access different receptor populations. |
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| Keywords: | Sar1 Ile8-angiotensin II Angiotensin II Transport Vascular compartment Cerebroventricular compartment |
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