The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A |
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Authors: | Joerg Kallen Malcolm D Walkinshaw |
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Institution: | Preclinical Research, Sandoz Pharma AG, Basel, Switzerland. |
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Abstract: | Human cyclophilin A (165 residues) has peptidyl-prolyl cis-trans isomerase activity. Here we report a high-resolution three-dimensional X-ray structure of a substrate, ac-Ala-Ala-Pro-Ala-amc (ac. acetyl: amc. amidomethylcoumarin) bound to the active-site of cyclophilin. The structure consisting of a dimer of complexes and 135 water molecules was refined to a crystallographic R-factor of 17.7% for all data in the range 8 Å-2.3 Å. |
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Keywords: | X-ray structure cis-trans Isomerase Cyclophilin |
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