Transition metal abnormalities in progressive dementias |
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| Authors: | Hiroyasu Akatsu Akira Hori Takayuki Yamamoto Mari Yoshida Maya Mimuro Yoshio Hashizume Ikuo Tooyama Eric M Yezdimer |
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| Institution: | (1) Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan;(2) Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan;(3) Research Promotion Organization for Intractable Neurological Disease, Molecular Neuroscience Research Center, Shiga Medical University, Otsu, Japan;(4) State College, PA, USA;(5) Industrial Summit Technology, Parlin, NJ, USA; |
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| Abstract: | Abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous
system diseases, including Alzheimer’s disease (AD), Parkinson’s disease, dementia with Lewy bodies (DLB), bipolar disorders
and depression. To further explore this possibility, the total concentrations of iron, zinc, copper, manganese, aluminum,
chromium and cadmium were measured in post-mortem hippocampus and amygdala tissues taken from AD, DLB and Control patients.
A statistically significant near fifty percent reduction in the total copper levels of AD patients was observed in both the
hippocampus and amygdala. The statistical power of the hippocampus and amygdala copper analysis was found to be 86 and 74%
respectively. No statistically significant deviations in the total metal concentrations were found for zinc, manganese, chromium
or aluminum. Iron was found to be increased by 38% in AD amygdala tissues, but was unchanged in AD hippocampus tissues. Accounting
for differences in tissue water content, as a function of both tissue type and disease state, revealed more consistencies
with previous literature. To aid in the design of future experiments, the effect sizes for all tissue types and metals studied
are also presented. |
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