Liver as a source of transformed cell growth factor |
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Authors: | Elizabeth Witkoski Mary F. Schuler Richard C. Feldhoff Samson I. Jacob Leonard S. Jefferson Allan Lipton |
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Abstract: | Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000–70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity—44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor. |
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