Reduced Hippocampal Cell Differentiation in the Subgranular Zone of the Dentate Gyrus in a Rat Model of Type II Diabetes |
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Authors: | In Koo Hwang Sun Shin Yi Yo Na Kim Il Yong Kim In Se Lee Yeo Sung Yoon Je Kyung Seong |
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Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea |
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Abstract: | It has recently been reported that diabetes mellitus is strongly associated with neurodegenerative and functional disorders
of the central nervous system. In the present study, we investigated the changes in proliferating neurons in the dentate gyrus
of type II diabetic rats using doublecortin (DCX), a marker of progenitors differentiating into neurons. At 4 weeks after
birth, there were no differences in the blood glucose levels of Zucker diabetic fatty (ZDF) rats or Zucker lean control (ZLC)
rats. DCX-immunoreactive neurons were detectable in the subgranular zone of the dentate gyrus in both the ZDF and ZLC rats;
however, DCX immunoreactivity was higher in the ZLC rats than in the ZDF rats. At 12 weeks after birth, the blood glucose
level was significantly increased by 400 mg/dl in the ZDF rats, but the blood glucose level in the ZLC rats was only slightly
increased by 152.3 mg/dl. DCX immunoreactivity was significantly decreased in 12-week-old rats in comparison to 4-week-old
rats. Some DCX-immunoreactive neurons were detectable in the subgranular zone of the dentate gyrus in the ZLC rats. However,
only a few DCX-immunoreactive neurons were observed in the ZDF rats, and the DCX-immunoreactive neurons in the ZDF rats did
not show fully developed processes. These results suggest that DCX-immunoreactive neurons were significantly decreased in
an age-dependent manner and that DCX-immunoreactive neurons were also reduced in diabetic rats. In addition, the reduction
in DCX-immunoreactive neurons in age matched rats may be associated with type II diabetes. |
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Keywords: | Type II diabetes Dentate gyrus Zucker rat Neurogenesis Doublecortin |
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