Caenorhabditis elegans is a model host for Listeria monocytogenes |
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Authors: | Thomsen Line E Slutz Sandra S Tan Man-Wah Ingmer Hanne |
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Institution: | Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University (KVL), Stigb?jlen 4, DK-1870 Frederiksberg C, Denmark. |
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Abstract: | Here we report that Caenorhabditis elegans nematodes fed Listeria monocytogenes die over the course of several days, as a consequence of an accumulation of bacteria in the worm intestine. Mutant strains previously shown to be important for virulence in mammalian models were also found to be attenuated in their virulence in C. elegans. However, ActA, which is required for actin-based intracellular motility, appears to be dispensable during infection of C. elegans, indicating that L. monocytogenes remains extracellular in C. elegans. |
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