Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor |
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| Authors: | Chen Zhengming Davies Ellen Miller Wendy S Shan Shen Valenzano Kenneth J Kyle Donald J |
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| Institution: | Drug Discovery Research, Purdue Pharma L.P., 6 Cedar Brook Drive, Cranbury, NJ 08512, USA. zhengming_chen@hotmail.com |
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| Abstract: | Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series. |
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