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Infectious particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes. |
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| Authors: | I Lebedeva K Fujita A Nihrane J Silver |
| Abstract: | Semliki Forest virus vectors encoding murine leukemia virus (MLV) envelope protein with a truncated cytoplasmic tail generate submicrometer, cell-associated, membranous particles that transmit replication-competent vector RNA specifically to cells bearing the MLV receptor. Such "minimal" viruses could have applications as retroviral vaccines or in the study of virus evolution. |
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