| What does 'chromatin remodeling' mean? |
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| 引用本文： | Aalfs JD,Kingston RE. What does 'chromatin remodeling' mean?[J]. Trends in biochemical sciences, 2000, 25(11): 548-555. DOI: 10.1016/S0968-0004(00)01689-3 |
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| 作者姓名： | Aalfs JD Kingston RE |
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| 摘 要： |
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What does ‘chromatin remodeling’ mean? |
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| Aalfs J D,Kingston R E. What does ‘chromatin remodeling’ mean?[J]. Trends in biochemical sciences, 2000, 25(11): 548-555. DOI: 10.1016/S0968-0004(00)01689-3 |
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| Authors: | Aalfs J D Kingston R E |
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| Affiliation: | Dept of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. |
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| Abstract: | The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro. |
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