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The effect of estradiol on isolated rat uterine motility and on prostaglandin generation
Authors:N. Sterin-Speziale   M.F. Gimeno   A. Bonacossa  A.L. Gimeno  
Affiliation:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V.de Obligado 2490. 1428 Buenos Aires, ARGENTINA
Abstract:The motility of isolated uterine horns as well as the generation of PGE and PGF like material by the uterus from estrus and spayed rats, treated or untreated with 17-beta estradicl, were studied. Following 40 minutes of mounting the spontaneous motility of uteri from estrus rats had a lower magnitude than that from spayed ones. The amount of PGF-like material was similar in both groups whereas the first one liberated less PGE-like substance. In spayed animals treated with 1 μg of 17-beta estradiol the decay of spontaneous contractile force was higher than that observed in untreated rats, and similar to that displayed by uteri from estrus. Less PGE-like material was liberated in comparison with spayed animals and a tendency to produce higher quantity of PGF-like compounds was observed, although the level was not significantly different. With 50 μg of 17-beta estradiol the spontaneous reduction of contractile activity was higher than in spayed animals and than in those treated with 1 μg. The amount of PGF-like material liberated was higher than in spayed rats and less PGE-like substance was generated comparing with spayed and 1 μg-treated animals. These findings show that estradiol decreases the release of PGE-like compound. It would also appear that this may have some relationship with the levels of spontaneous contractile activity of the isolated rat uterus.
Keywords:Mailing Address: A.L. GIMENO   M.D. V. de Obligado 2490 1428 Buenos Aires   ARGENTINA
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