Levels of the Vsr Endonuclease Do Not Regulate Stationary-Phase Reversion of a Lac− Frameshift Allele in Escherichia coli |
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Authors: | Patricia L Foster and William A Rosche |
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Institution: | Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118-2394 |
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Abstract: | Vsr endonuclease, which initiates very short patch repair, has been hypothesized to regulate mutation in stationary-phase cells. Overexpression of Vsr does dramatically increase the stationary-phase reversion of a Lac− frameshift allele, but the absence of Vsr has no effect. Thus, at least in this case, Vsr has no regulatory role in stationary-phase mutation, and the effects of Vsr overproduction are likely to be artifactual. |
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