| Abstract: | Humoral and cellular aspects of the immune response of the common dogfish (Scyliorhinus canicula L.) to a variety of cellular antigens have been examined. The fish made a relatively slow but positive antibody response to injected Salmonella typhi. Using the haemolytic plaque technique, antibody synthesis was shown to occur in the spleen after fish were challenged with sheep red blood cells, suggesting that this organ is a major site of antibody synthesis. Intraperitoneal and intravenous injections of allogeneic leucocytes stimulated marked histological changes in the spleens of recipients, indicative of a host-vs-graft reaction and suggesting that the fish are capable of alloimmune reactions. |
