Autophagy and human diseases |
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Authors: | Peidu Jiang Noboru Mizushima |
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Institution: | 1.Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;2.Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan |
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Abstract: | Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to the lysosome for degradation. Since the discovery of autophagy-related (Atg) genes in the 1990s, there has been a proliferation of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models. However, direct evidence of the connections between ATG gene dysfunction and human diseases has emerged only recently. There are an increasing number of reports showing that mutations in the ATG genes were identified in various human diseases such as neurodegenerative diseases, infectious diseases, and cancers. Here, we review the major advances in identification of mutations or polymorphisms of the ATG genes in human diseases. Current autophagy-modulating compounds in clinical trials are also summarized. |
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Keywords: | autophagy lysosome neurodegeneration Parkinson''s disease mitophagy Crohn''s disease SENDA |
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