Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon |
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Authors: | H Hayashi K Tanaka F Jay G Khoury G Jay |
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Institution: | 1. Laboratory of Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA;2. Department of Medical Microbiology University of Manitoba Winnipeg, Manitoba R3E OW3, Canada |
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Abstract: | Human adenovirus-12-transformed cells express greatly reduced levels of the major histocompatibility complex class I antigens and are highly tumorigenic in syngeneic hosts. The finding that expression of a transfected class I gene is sufficient to abrogate their tumorigenicity underscores the importance of defining the conditions that will lead to derepression of endogenous class I genes in these cells. Brief treatment of Ad12-transformed cells with interferon results in the rapid but transient expression of class I antigens, and these interferon-treated cells have significantly reduced tumorigenicity in immunocompetent hosts. We have further demonstrated that subcutaneous administration of interferon, subsequent to the introduction of a tumorigenic dose of Ad12-transformed cells, results in complete protection against this tumor. The ability of interferon to "induce" class I gene expression may be an important modality in the treatment of a variety of spontaneous tumors that exhibit greatly reduced levels of class I antigens on their cell surface. |
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