EMT参与肿瘤侵袭转移的研究进展

在癌症类型中,上皮癌占绝大多数。从良性腺瘤过渡到恶性癌和转移期间,上皮肿瘤细胞获得去分化、迁移和入侵行为,同时上皮-间质转化（epithelial-mesenchymal transition EMT）伴随着显著的细胞形态学变化、细胞与细胞间及细胞与基质之间的粘附性丢失及重塑、并获得迁徙和侵袭能力。正如完全分化的上皮细胞转换成低分化、迁移和侵入性间质细胞,其涉及到一个高度的细胞可塑性、大量不同的基因和表观遗传学改变,因此EMT本身是一个多阶段的过程。该综述的目的是系统地总结EMT分子机制及EMT与肿瘤关系的最新进展。

The Research Progress of EMT in Tumor Invasion and Metastasis

Epithelial cancers make up the vast majority of cancer types, and during the transition from benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de-differentiated, migratory and invasive behavior. This process of epithelial-mesenchymal transition（EMT） goes along with dramatic changes in cellular morphology, the loss and remodeling of cell-cell and cell-matrix adhesions, and the gain of migratory and invasive capabilities. As fully differentiated epithelial cells convert into poorly differentiated, migratory and invasive mesenchymal cells, EMT itself is a multistage process, involving a high degree of cellular plasticity and a large number of distinct genetic and epigenetic alterations. The aim of this review is to summarize the newest advances of EMT and tumors.