Toll-like receptor 8 polymorphism and coronary artery disease |
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Authors: | Zhong Chen Genshan Ma Qi Qian Yuyu Yao Yi Feng Chengchun Tang |
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Institution: | (1) Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, NO. 87 Dingjiaqiao, Hunan Road, Nanjing, 210009, People’s Republic of China |
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Abstract: | Toll-like receptors (TLRs) play roles in innate and adaptive immune responses. Some TLRs are involved in the pathogenesis
of cardiovascular diseases. Coronary artery disease (CAD) has an inflammatory and immunological basis. We investigated whether
TLR8 Met1Val and TLR8-129G>C single nucleotide polymorphisms (SNPs rs3764879 and rs3764880) are associated with CAD in the
Chinese population. We enrolled 412 consecutive patients (185 with coronary stenosis ≥50% or previous myocardial infarction
and 227 controls). Ligase detection reaction was performed to detect SNPs rs3764879 and rs3764880 of TLR8. The SNP at rs3764879
is in complete linkage disequilibrium with rs3764880. No significant difference was found in genotypic or allelic frequencies
of these two common SNPs between CAD cases and controls (P > 0.05, respectively). No associations existed between these two SNPs and the severity of coronary artery stenosis (All P > 0.05). These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
Z. Chen and G. Ma contributed equally to this paper. |
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Keywords: | Coronary artery disease Single nucleotide polymorphisms Toll-like receptors |
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