Quantitative expression of TEL in childhood acute lymphoblastic leukemia |
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Authors: | Timson G Gutiérrez M I Bhatia K |
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Institution: | King Fahad National Centre for Children's Cancer and Research, Riyadh, Saudi Arabia. |
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Abstract: | Loss of heterozygosity of chromosome 12p in human precursor B-cell ALL invariably results in loss of TEL coding sequences. Accompanied by a 12;21 translocation, such loss of heterozygosity ensures complete loss of the wild-type TEL. No inactivating mutations of the retained TEL allele have been reported in leukemias with hemizygous deletion. However, only minimal data reported the expression of the wild-type TEL in ALL. We now demonstrate that quantitative real-time RT-PCR from leukemic RNA samples could be indicative of compromised TEL expression in childhood ALL and therefore loss of TEL function. |
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