| 新生大鼠脊髓薄片交感节前神经元的长时程后超极化电位 |
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| 引用本文： | 汪萌芽.新生大鼠脊髓薄片交感节前神经元的长时程后超极化电位[J].生理学报,1994(1). |
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| 作者姓名： | 汪萌芽 |
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| 作者单位： | 皖南医学院细胞电生理研究室 |
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| 摘 要： | 在新生大鼠胸腰段脊髓薄片，对经腹根逆行刺激鉴定的交感节前神经元（ＳＰＮｓ）进行细胞内记录．发现部分ＳＰＮｓ有长时程后超极化电位（１１－ＳＨＰ），其达峰时间为０．２－０．７ｓ．时程１－１０ｓ，幅度７－２０ｍＶ。１１－ＡＨＰ前部常为６—３０ｍｓ达峰、短于４００ｍｓ时程的快ＡＨＰ成分。１１－ＡＨＰ除伴有膜输入电阻降低外，还呈膜电位依赖性，翻转电位为－９０至－１００ｍＶ。结果证明１１－ＡＨＰ能起着控制ＳＰＮ的放电频率的重要作用。
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| 关 键 词： | 脊髓 交感节前神经元 后超极化电位 大鼠 |
LONG-LASTING AFTERHYPERPOLARIZATION OF SYMPATHETIC PREGANGLIONIC NEURONS OF NEONATE RAT SPINAL CORD SLICES |
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| WANG MENG-YA.LONG-LASTING AFTERHYPERPOLARIZATION OF SYMPATHETIC PREGANGLIONIC NEURONS OF NEONATE RAT SPINAL CORD SLICES[J].Acta Physiologica Sinica,1994(1). |
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| Authors: | WANG MENG-YA |
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| Abstract: | Intracellular recordings of antidromically indentified sympathetic preganglionic neurons(SPNs) were made in thoracolumbar spinal cord slices from neonate rats (7-16 days). In the SPNs population, a 7-20 mV long-lasting afterhyperpolarization(11-AHP) lasting for 1 to 10 s following spike potential could be recorded in part of the neurons and the 11-AHPs was usually preceded by a fast component lasting shorter than 400 ms. With decrease of membrane resistance during 11-AHP, membrane potential-dependent property was observed and the calculated reversal potential was -90 to -100 mV. The results indicate that the 11-AHPs are effective in the control of firing frequency of SPNs. |
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| Keywords: | spinal cord sympathetic preganglionic neuron afterhyperpolarization rat |
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