DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections |
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Authors: | French Anthony R Sjölin Hanna Kim Sungjin Koka Rima Yang Liping Young Deborah A Cerboni Cristina Tomasello Elena Ma Averil Vivier Eric Kärre Klas Yokoyama Wayne M |
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Institution: | Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. french_a@kids.wustl.edu |
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Abstract: | NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H. The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its virally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate. |
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