Two novel cyclic hexapeptides from the genetically engineered Actinosynnema pretiosum |
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Authors: | Lu Chunhua Xie Fei Shan Chuan Shen Yuemao |
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Institution: | 1.Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, 250012, People’s Republic of China ;2.School of Chemistry and Chemical Engineering|, Shandong University, Jinan, Shandong, 250100, People’s Republic of China ; |
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Abstract: | Two novel cyclic hexapeptides designated actinosynneptides A (1) and B (2), together with three tryptophan containing diketopiperazines, namely cyclo(L-Trp-L-Trp) (3), cyclo(L-Trp-N-MeL-Trp) (4), and cyclo(N-MeL-Trp-N-MeL-Trp) (5), were isolated from the culture of the genetically engineered strain HGF052::asm18 derived from Actinosynnema pretiosum ATCC31565. Their structures were elucidated on the basis of spectroscopic analyses and single-crystal X-ray diffractions. Compound 1 is the first example of 3-amino-6-hydroxy-2-piperidone-containing cyclic peptides, and 1 and 2 showed moderate cytotoxic activities against HeLa and PC3 cell lines. |
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