Cyanide bioremediation: the potential of engineered nitrilases |
| |
Authors: | Park Jason M Trevor Sewell B Benedik Michael J |
| |
Institution: | 1.Department of Biology, Texas A&M University, College Station, TX, 77843-3258, USA ;2.Structural Biology Research Unit, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, 7925, South Africa ; |
| |
Abstract: | The cyanide-degrading nitrilases are of notable interest for their potential to remediate cyanide contaminated waste streams, especially as generated in the gold mining, pharmaceutical, and electroplating industries. This review provides a brief overview of cyanide remediation in general but with a particular focus on the cyanide-degrading nitrilases. These are of special interest as the hydrolysis reaction does not require secondary substrates or cofactors, making these enzymes particularly good candidates for industrial remediation processes. The genetic approaches that have been used to date for engineering improved enzymes are described; however, recent structural insights provide a promising new approach. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|