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Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes
Authors:Zhao  Wei  Fan  Aili  Tarcz  Sylwia  Zhou  Kang  Yin  Wen-Bing  Liu  Xiao-Qing  Li  Shu-Ming
Institution:1.College of Life Sciences, Capital Normal University, No.105 Xisanhuan Beilu, Beijing, 100048, China
;2.Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, 35037, Marburg, Germany
;3.State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
;
Abstract:Applied Microbiology and Biotechnology - The fungal cyclic dipeptide prenyltransferase FtmPT1 from Aspergillus fumigatus catalyzes a regular C2-prenylation of brevianamide F (cyclo-l-Trp-l-Pro) and...
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