ADP-Ribosylation: Activation,Recognition, and Removal |
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| Authors: | Nan Li Junjie Chen |
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| Institution: | Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA |
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| Abstract: | ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions. |
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| Keywords: | ADP-Ribosylation PARG PARP PAR recognition domain |
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