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C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells |
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| Authors: | Jiang Shanshan Wang Qian Feng Meiqing Li Jiyang Guan Zhongbin An Duopeng Dong Mengxue Peng Yuzhe Kuerban Kudelaidi Ye Li |
| Affiliation: | 1.Department of Biosynthesis and Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China ;2.Shanghai Institute For Food And Drug Control, Shanghai, China ; |
| Abstract: | Applied Microbiology and Biotechnology - Sorafenib as an effective multikinase inhibitor has been approved for the clinical treatment against advanced hepatocellular carcinoma (HCC). HCC treatment... |
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