Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy

Authors:	Christopher M Vickery Richard Lockey Thomas M Holder Leigh Thorne Katy E Beck Christina Wilson Margaret Denyer John Sheehan Sarah Marsh Paul R Webb Ian Dexter Angela Norman Emma Popescu Amanda Schneider Paul Holden Peter C Griffiths Jane M Plater Mark P Dagleish Stuart Martin Glenn C Telling Marion M Simmons John Spiropoulos

Affiliation:	^aAnimal Health and Veterinary Laboratories Agency (AHVLA) Weybridge, Addlestone, Surrey, United Kingdom ;^bMoredun Research Institute, Bush Loan, Penicuik, Midlothian, United Kingdom;^cPrion Research Center, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

Abstract:	Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536^+/−, to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536^+/− mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.

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