Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats |
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| Authors: | Rosa Lippolis Paola Morini Anna Rosa Conserva Elisabetta Casalino Elemente Landriscina |
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| Affiliation: | (1) Research Unit on Mitochondria and Energy Metabolism, National Research Council, Via Amendola 165/A, 70126 Bari, Italy;(2) Present address: Institute of Chemistry, Laboratory of Biochemistry, Faculty of Veterinary Medicine, University of Bari, Via Gentile 182, 70126 Bari, Italy |
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| Abstract: | Summary Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both the liver and the heart mitochondria of hyperthyroid rats is reduced by about 35% [l2] but this reduction is not due to changes in membrane fluidity in either tissue. Hypothyroidism, on the other hand, affects BDH activity in neither heart nor liver.Abbreviations BDH D-3-hydroxybutyrate dehydrogenase - PTU 6n-propyl-2-thiouracil - T3,3,3 5-L-triiodothyronine - Tm temperature phase transition - Ea apparent activation energy |
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| Keywords: | D-3-hydroxybutyrate dehydrogenase hyperthyroidism hypothyroidism hormonal enzyme regulation fatty acids |
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